Description

Upanib 15mg Tablet (Upadacitinib) – Uses, Side Effects, Dosage & Price in Pakistan

Upanib 15mg Tablet contains upadacitinib, a medicine belonging to the Janus kinase (JAK) inhibitor class. It is supplied as an extended-release film-coated tablet containing upadacitinib equivalent to 15 mg. According to the manufacturer’s prescribing information, Upanib is indicated for adults with moderate to severe active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.

Upadacitinib works by reducing certain immune-system signals involved in inflammation. Because it affects the immune system, it is a prescription medicine that should be used under medical supervision. Doctors may also monitor blood counts, liver enzymes and other laboratory values during treatment.

What Is Upanib 15mg Tablet (Upadacitinib)?

Upanib 15mg Tablet is an extended-release oral tablet containing upadacitinib hemihydrate equivalent to 15 mg of upadacitinib. It is manufactured by Ziska Pharmaceuticals Ltd., Bangladesh, according to the manufacturer’s product information.

Upadacitinib belongs to a group of medicines called Janus kinase (JAK) inhibitors or immunosuppressants. It is designed to reduce abnormal immune activity and inflammation.

The specific Upanib prescribing information lists its indication as treatment of moderate to severe active rheumatoid arthritis in adults who have not responded adequately to, or cannot tolerate, methotrexate. It may be used alone or together with methotrexate or other non-biologic DMARDs, according to the doctor’s decision.

Upanib 15mg Tablet Uses

The manufacturer’s prescribing information identifies rheumatoid arthritis as the indication for Upanib 15mg.

Rheumatoid arthritis is a long-term inflammatory condition in which the immune system mistakenly attacks tissues around the joints. This can cause joint pain, swelling, stiffness and difficulty with movement.

Upanib may be prescribed for adults with moderate to severe active rheumatoid arthritis when treatment with methotrexate has not worked adequately or is not tolerated. The medicine may be prescribed on its own or alongside certain non-biologic disease-modifying antirheumatic drugs.

Upadacitinib as an active ingredient has broader approved uses in some countries, including certain forms of psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn’s disease and axial spondyloarthritis. However, approvals and product indications differ by country and brand. Patients should therefore check the specific package insert and follow their doctor’s prescription rather than assuming that every 15 mg upadacitinib product has all of these indications.

How Does Upadacitinib Work?

Upadacitinib is a JAK inhibitor. JAK enzymes help transmit signals from various inflammatory substances in the body to cells.

By inhibiting JAK-related signaling, upadacitinib reduces some of the immune signals that contribute to inflammation. This can help control inflammatory activity associated with rheumatoid arthritis.

In simple terms, the medicine helps turn down specific inflammatory signals in the immune system rather than broadly stopping the immune system from working.

Upanib 15mg Tablet Dosage

The manufacturer’s prescribing information recommends 15 mg once daily for the rheumatoid arthritis indication described for Upanib.

The appropriate dose for an individual patient can be different depending on the disease being treated, response to treatment, other medicines and medical conditions. Upadacitinib dosing may also vary for different approved indications and patient groups.

Do not increase, decrease or stop Upanib without medical advice. The manufacturer’s information also recommends avoiding initiation or interrupting treatment when certain blood counts are below specified levels, including an absolute lymphocyte count below 500 cells/mm³, absolute neutrophil count below 1,000 cells/mm³ or haemoglobin below 8 g/dL.

How to Take Upanib 15mg Tablet

Upanib is taken by mouth once daily as prescribed.

Because it is an extended-release tablet, it should be taken according to the product’s instructions and should not be altered unless a healthcare professional specifically advises otherwise. The FDA labeling for upadacitinib extended-release tablets states that the tablets should not be split, crushed or chewed.

Take the medicine at approximately the same time each day. If you miss a dose, do not take an extra dose to compensate unless your doctor or pharmacist specifically instructs you to do so.

Upanib 15mg Tablet Side Effects

Like other medicines, Upanib can cause side effects.

The manufacturer’s prescribing information lists the following adverse reactions occurring at or above 1%:

• Upper respiratory tract infections
• Nausea
• Cough
• Fever (pyrexia)

More serious problems are also possible because upadacitinib suppresses parts of the immune system. Serious infections, including tuberculosis, can occur. Upadacitinib labeling also carries important warnings concerning malignancy, major cardiovascular events and thrombosis.

Seek prompt medical attention for symptoms such as persistent or severe infection, difficulty breathing, chest pain, sudden weakness, severe abdominal pain, unusual swelling or pain in an arm or leg, or signs of a serious allergic reaction.

Precautions and Warnings

Before starting Upanib, tell your doctor about your complete medical history and all medicines you take.

Important precautions include:

• Infections: Upadacitinib can increase the risk of serious infections. Active serious infections should be addressed before treatment.
• Tuberculosis: Patients may need assessment for tuberculosis before and during treatment.
• Blood tests: Blood counts, liver enzymes and lipids may need monitoring.
• Blood clots and cardiovascular problems: JAK inhibitors have important warnings concerning thrombosis and major cardiovascular events.
• Cancer: Malignancies have been reported with upadacitinib and other JAK inhibitors.
• Vaccines: Live vaccines should generally be avoided during treatment.
• Liver disease: The Upanib prescribing information states that it is not recommended in severe hepatic impairment.

Patients should tell their doctor if they have a history of recurrent infections, tuberculosis exposure, blood clots, heart disease, cancer or significant liver problems.

Upanib 15mg Tablet Drug Interactions

Upadacitinib is affected by medicines that strongly influence the CYP3A4 enzyme.

Strong CYP3A4 inhibitors, such as ketoconazole, can increase upadacitinib exposure. Strong CYP3A4 inducers, such as rifampin, can decrease exposure and may reduce its therapeutic effect. The manufacturer’s information advises caution with strong CYP3A4 inhibitors and does not recommend coadministration with strong CYP3A4 inducers.

Always provide your doctor or pharmacist with a complete list of prescription medicines, over-the-counter products and supplements before starting treatment.

Pregnancy and Breastfeeding

Upadacitinib may cause fetal harm based on animal studies, while available human pregnancy data are limited. Women who can become pregnant should discuss effective contraception and pregnancy planning with their healthcare provider.

The Upanib prescribing information advises women not to breastfeed during treatment.

If you are pregnant, planning pregnancy or breastfeeding, speak with your doctor before taking Upanib.

Upanib 15mg Tablet Storage

The manufacturer’s prescribing information states that Upanib should be stored at or below 25°C, protected from light and kept out of reach of children.

Keep the tablets in their original packaging and protect them from unsuitable storage conditions. Always follow the storage instructions printed on the pack you receive.

Upanib 15mg Tablet Manufacturer

Upanib is manufactured by Ziska Pharmaceuticals Ltd., with the manufacturer’s information giving its location as Kaliakoir, Gazipur, Bangladesh. Ziska’s official product page identifies Upanib as containing upadacitinib hemihydrate.

The exact pack size may vary between markets. The manufacturer’s product page currently lists a 3 × 10-tablet pack, while the prescribing information identifies a 1 × 10-tablet blister presentation. Therefore, check the actual packaging supplied in your market.

Upanib 15mg Tablet Price in Pakistan

The price of Upanib 15mg Tablet in Pakistan can vary depending on pack size, supplier, import status, availability and market conditions.

Rather than relying on an old or unofficial price, patients can check the current price and availability on Impo Medic before placing an order.

Buy Upanib 15mg Tablet in Pakistan

If Upanib 15mg has been prescribed for you, you can check Impo Medic for current product availability, pricing and ordering information.

As Upanib contains a JAK inhibitor and is a prescription medicine, it should be used only according to the instructions of a qualified healthcare professional. Do not purchase or start treatment based only on online information.

When ordering, check the product name, strength, pack size, expiry date and packaging. If there is any uncertainty about the product or prescription, consult a pharmacist or doctor before use.

Why Choose Impo Medic?

Impo Medic can help customers by providing:

• Clear and easy-to-understand medicine information
• Convenient online ordering
• Current product availability information
• Transparent pricing where available
• Information about imported medicines where applicable
• Customer support for product-related questions
• Responsible medicine-use guidance

Availability and pricing can change, particularly for specialty medicines, so customers should confirm current details before ordering.

FAQs About Upanib 15mg Tablet (Upadacitinib)

What is Upanib 15mg Tablet used for?

Upanib 15mg contains upadacitinib and, according to the manufacturer’s prescribing information, is used for adults with moderate to severe active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.

What is the active ingredient in Upanib 15mg?

The active ingredient is upadacitinib, supplied as upadacitinib hemihydrate equivalent to 15 mg of upadacitinib per extended-release tablet.

How should Upanib 15mg be taken?

The manufacturer’s recommended dose for its listed rheumatoid arthritis indication is 15 mg once daily. Take it exactly as prescribed and do not change the dose without medical advice.

What are the common side effects of Upanib?

Commonly reported reactions in the manufacturer’s information include upper respiratory tract infections, nausea, cough and fever.

Can Upanib be taken with other medicines?

It can interact with medicines that strongly affect CYP3A4, including ketoconazole and rifampin. Tell your doctor about all medicines you take before starting Upanib.

Is Upanib 15mg available in Pakistan?

Availability can vary by supplier and market conditions. Check Impo Medic for current availability rather than relying on an old stock listing.

What is the price of Upanib 15mg in Pakistan?

There is no single permanent market price. The cost may vary according to pack size, supplier, import status and availability. Check Impo Medic for the current listed price.

Is a prescription required for Upanib?

Upadacitinib is a prescription medicine and should be used under the supervision of a qualified healthcare professional.