Description

Trifluxen 15mg & 6.14mg Tablet (Trifluridine and Tipiracil) – Uses, Side Effects, Dosage & Price in Pakistan

Trifluxen 15mg & 6.14mg Tablet (Trifluridine and Tipiracil) is an oral anticancer medicine containing two active ingredients, trifluridine and tipiracil. This combination is used in specific treatment settings for adults with certain advanced or metastatic cancers, including metastatic colorectal cancer and metastatic gastric or gastroesophageal junction adenocarcinoma after previous chemotherapy.

Trifluxen should be used only under the supervision of an oncologist. Treatment may require regular blood tests because this medicine can cause significant decreases in blood-cell counts.

What Is Trifluxen 15mg & 6.14mg Tablet?

Trifluxen 15mg & 6.14mg Tablet contains two active ingredients:

• Trifluridine – 15mg
• Tipiracil – 6.14mg

The combination belongs to an anticancer treatment approach in which trifluridine interferes with cancer-cell DNA synthesis, while tipiracil helps increase the amount of trifluridine available in the body by inhibiting its breakdown.

The reference Lonsurf product with this strength is a white, round, film-coated tablet intended for oral administration. Each tablet contains 15mg trifluridine and 6.14mg tipiracil.

Trifluxen 15mg & 6.14mg Uses

Trifluridine and tipiracil may be prescribed for adults with certain advanced cancers.

Metastatic Colorectal Cancer

The combination is indicated for adults with metastatic colorectal cancer who have previously received specified chemotherapy and targeted treatments. It may be used alone or in combination with bevacizumab in appropriate patients.

Metastatic Gastric Cancer

It is also indicated for adults with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two lines of chemotherapy containing specified medicines, including a fluoropyrimidine and platinum-based treatment.

The exact treatment choice depends on the cancer type, previous treatments, overall health and the oncologist’s assessment.

How Does Trifluridine and Tipiracil Work?

Trifluridine is a nucleoside analogue that can be incorporated into the DNA of cancer cells. This interferes with DNA synthesis and helps inhibit the growth and multiplication of cancer cells.

Tipiracil inhibits thymidine phosphorylase, an enzyme involved in the breakdown of trifluridine. By slowing this breakdown, tipiracil increases exposure to trifluridine and helps maintain its activity.

Together, these two ingredients provide the anticancer activity of the combination.

Trifluxen 15mg & 6.14mg Dosage

The dose of trifluridine and tipiracil is calculated according to the patient’s body surface area (BSA) and is prescribed by the treating oncologist.

The recommended dose of the reference combination is 35mg/m² per dose, taken orally twice daily with food, up to a maximum of 80mg per dose based on the trifluridine component.

Treatment is generally taken on:

• Days 1–5
• Days 8–12

of each 28-day treatment cycle, usually until disease progression or unacceptable toxicity.

Because the 15mg/6.14mg tablet is combined with the 20mg/8.19mg strength to achieve the required dose, the number of tablets can vary between patients.

Do not calculate or change your own cancer-medicine dose. The oncologist determines the appropriate dose based on body surface area, blood counts, kidney function, side effects and other clinical factors.

How to Take Trifluxen 15mg & 6.14mg Tablet

Take Trifluxen exactly as prescribed by your oncologist.

• Take the medicine with food.
• Take it twice daily on the scheduled treatment days.
• Swallow the tablets whole.
• Take the doses at approximately the prescribed times.
• Do not take an extra dose if a dose is missed.
• Do not repeat a dose if vomiting occurs.
• Continue with the next scheduled dose according to your treatment plan.

Trifluridine and tipiracil is a cytotoxic medicine, so appropriate handling and disposal procedures should be followed.

Trifluxen 15mg & 6.14mg Tablet Side Effects

Like other anticancer medicines, Trifluxen can cause side effects. The severity can vary between patients.

Possible side effects include:

• Tiredness or weakness
• Nausea
• Vomiting
• Diarrhea
• Reduced appetite
• Abdominal discomfort
• Fever
• Mouth sores
• Headache
• Changes in blood-cell counts

One of the most important risks is myelosuppression, which means the medicine can reduce the production of blood cells. This can lead to low white blood cells, low red blood cells and low platelets.

Serious Side Effects of Trifluxen 15mg & 6.14mg Tablet

Low blood counts can sometimes become severe or life-threatening. Low white blood-cell counts can increase the risk of serious infections.

Contact your healthcare professional promptly if you experience:

• Fever or signs of infection
• Unusual bleeding or bruising
• Severe weakness
• Shortness of breath
• Persistent vomiting or diarrhea
• Severe or worsening symptoms

Your doctor may delay treatment, reduce the dose or temporarily stop the medicine if blood counts or other side effects become concerning.

Trifluxen 15mg & 6.14mg Tablet Precautions

Before starting Trifluxen, tell your doctor about your complete medical history and all medicines you take.

Particular attention may be required if you have:

• Kidney problems
• Liver problems
• Previous problems with low blood-cell counts
• A history of severe reactions to similar medicines
• Other medical conditions requiring regular medication

Blood tests are an important part of treatment. The prescribing information recommends checking complete blood counts before treatment and again on Day 15 of each treatment cycle, as well as when clinically necessary.

Patients with severe renal impairment may require a lower dose, while the medicine should not be initiated in patients with baseline moderate or severe hepatic impairment under the reference prescribing information.

Trifluxen 15mg & 6.14mg Drug Interactions

Tell your oncologist about every prescription medicine, over-the-counter medicine, vitamin and supplement you use.

Your doctor or pharmacist can check for clinically relevant interactions before treatment begins.

Do not start or stop another medicine without discussing it with your healthcare professional, particularly while receiving anticancer treatment.

Trifluxen During Pregnancy and Breastfeeding

Trifluridine and tipiracil can cause fetal harm. Women who can become pregnant should discuss effective contraception with their healthcare professional during treatment.

Men and women should discuss fertility considerations with their oncologist before treatment when relevant.

Breastfeeding should be discussed with a healthcare professional because of the potential risk to a breastfed infant.

Trifluxen 15mg & 6.14mg Storage

Store Trifluxen according to the instructions provided on the product packaging.

The reference 15mg/6.14mg trifluridine/tipiracil tablets are stored at 20°C to 25°C, with permitted excursions between 15°C and 30°C.

Keep the medicine in its original container when possible and protect it from inappropriate storage conditions. If the tablets are stored outside the original bottle, the reference labeling states that unused tablets should be discarded after 30 days.

Keep all medicines out of the reach of children.

Trifluxen 15mg & 6.14mg Tablet Manufacturer

The specific manufacturer of Trifluxen should be confirmed from the product packaging or verified manufacturer information.

For comparison, the reference branded product Lonsurf containing trifluridine and tipiracil is manufactured by Taiho Pharmaceutical Co., Ltd., Japan, and is manufactured for Taiho Oncology, Inc.

Do not assume that Trifluxen is manufactured by the same company unless its packaging or official product documentation confirms this.

Trifluxen 15mg & 6.14mg Price in Pakistan

The Trifluxen 15mg & 6.14mg Tablet price in Pakistan may vary depending on the supplier, pack size, import status, availability and market conditions.

Because anticancer medicines can have different prices depending on their source and packaging, the current price should be confirmed before ordering.

Customers can check the latest price and availability through Impo Medic.

Buy Trifluxen 15mg & 6.14mg Tablet in Pakistan

If you are looking for Trifluxen 15mg & 6.14mg Tablet in Pakistan, Impo Medic can provide product information and online ordering support, subject to availability.

Trifluxen is an anticancer prescription medicine and should be used only under the direction of a qualified oncologist. Before ordering, confirm the strength, pack size and product details carefully.

Patients should not start, stop or change their cancer treatment based only on information found online.

Why Choose Impo Medic?

• Easy access to medicine information
• Online ordering convenience
• Clear product and strength information
• Updated availability where possible
• Transparent pricing information
• Support for imported medicines where available
• Responsible approach to prescription and anticancer medicines

FAQs About Trifluxen 15mg & 6.14mg Tablet (Trifluridine and Tipiracil)

What is Trifluxen 15mg & 6.14mg used for?

It contains trifluridine and tipiracil and may be prescribed for certain adults with metastatic colorectal cancer or metastatic gastric/gastroesophageal junction adenocarcinoma after specified previous treatments.

What are the active ingredients in Trifluxen?

Each tablet contains 15mg trifluridine and 6.14mg tipiracil.

How should Trifluxen 15mg & 6.14mg be taken?

It is taken orally with food according to an oncologist’s prescribed schedule. The standard reference regimen uses treatment on Days 1–5 and Days 8–12 of a 28-day cycle, but the dose is individualized according to body surface area and other factors.

What are the common side effects of  Trifluxen 15mg & 6.14mg Tablet ?

Possible side effects include tiredness, nausea, vomiting, diarrhea, reduced appetite and abnormalities in blood-cell counts.

Can Trifluxen cause low blood counts?

Yes. Severe myelosuppression is an important warning associated with trifluridine and tipiracil. Regular blood-count monitoring is therefore important during treatment.

Can Trifluxen be used during pregnancy?

It can cause fetal harm. Anyone who is pregnant, planning pregnancy or able to become pregnant should discuss the medicine with their healthcare professional before treatment.

Is Trifluxen 15mg & 6.14mg available in Pakistan?

Availability can vary depending on supplier and import status. Check the current product availability with Impo Medic.

Does Trifluxen require a prescription?

Yes. It is an anticancer prescription medicine and should be used under specialist medical supervision.

Legal & Medical Disclaimer

This article is for general educational and informational purposes only. It does not replace a doctor’s diagnosis, prescription or medical advice. Trifluxen is an anticancer medicine that can cause serious side effects, including severe decreases in blood-cell counts. Always use it exactly as prescribed by your oncologist and follow recommended monitoring.