Description

Sotoxen 120mg Tablet (Sotorasib) – Uses, Dosage, Side Effects & Price in Pakistan

Sotoxen 120mg Tablet contains sotorasib, a targeted cancer medicine that works against tumors with a specific KRAS G12C mutation. Sotorasib is used in adults with certain locally advanced or metastatic non-small cell lung cancer (NSCLC) after at least one previous systemic treatment. It is also used with panitumumab for certain adults with KRAS G12C-mutated metastatic colorectal cancer after specific chemotherapy treatments.

Because sotorasib is a prescription oncology medicine, it should only be used under the supervision of a qualified oncologist and after appropriate molecular testing.

What Is Sotoxen 120mg Tablet?

Sotoxen 120mg Tablet contains sotorasib 120mg, an oral targeted therapy. Sotorasib belongs to a class of medicines that inhibit abnormal KRAS signaling.

The medicine is designed to target the KRAS G12C protein produced by cancer cells carrying this mutation. Blocking this abnormal signaling may help slow or stop the growth of cancer cells.

The reference FDA-approved product, Lumakras, is available in 120mg, 240mg, and 320mg tablet strengths.

Sotoxen 120mg Uses

Sotorasib may be prescribed for specific cancers with a confirmed KRAS G12C mutation.

KRAS G12C-mutated NSCLC

Sotorasib is indicated as a single-agent treatment for adults with locally advanced or metastatic non-small cell lung cancer whose tumors have a KRAS G12C mutation and who have received at least one previous systemic therapy.

KRAS G12C-mutated Colorectal Cancer

Sotorasib may also be used with panitumumab for adults with KRAS G12C-mutated metastatic colorectal cancer who have previously received chemotherapy containing a fluoropyrimidine, oxaliplatin, and irinotecan.

Sotorasib is not appropriate for every person with lung or colorectal cancer. Treatment selection depends on cancer type, mutation testing, previous treatments, and the patient’s overall medical condition.

How Does Sotorasib Work?

Sotorasib specifically targets the abnormal KRAS G12C protein. KRAS proteins are involved in signaling pathways that regulate cell growth. When KRAS is mutated, these signals can remain abnormally active and contribute to uncontrolled cancer-cell growth.

Sotorasib binds to the KRAS G12C mutant protein and inhibits its activity. This targeted action may help reduce signaling that supports tumor growth.

Sotoxen 120mg Dosage

The recommended FDA-labeled dose of sotorasib is 960mg once daily for both its approved NSCLC use and its use with panitumumab for KRAS G12C-mutated metastatic colorectal cancer.

Since Sotoxen is a 120mg tablet, a 960mg daily dose corresponds to eight 120mg tablets, when this dosing regimen is specifically prescribed.

Do not determine your dose yourself. Your oncologist may adjust or temporarily stop treatment if significant side effects occur. The labeled dose-reduction levels are 480mg once daily and then 240mg once daily.

How to Take Sotoxen 120mg Tablet

• Take sotorasib once daily at approximately the same time.
• It can be taken with or without food.
• Swallow tablets as directed by your doctor.
• Do not chew or crush the tablets.
• If you miss a dose by more than 6 hours, skip that dose and take the next dose at the usual time.
• Do not take two doses together to make up for a missed dose.
• If vomiting occurs after taking the medicine, do not take another dose that day. Take the next dose as scheduled.

For patients who have difficulty swallowing solid tablets, the FDA label provides specific instructions for dispersing the tablets in non-carbonated room-temperature water. This should be done only according to the prescribing instructions.

Sotoxen 120mg Side Effects

Like other cancer medicines, sotorasib can cause side effects. Common adverse reactions reported with sotorasib as a single agent for NSCLC include:

• Diarrhea
• Musculoskeletal pain
• Nausea
• Fatigue
• Liver toxicity
• Cough

Laboratory abnormalities can also include changes in liver enzymes, hemoglobin, lymphocytes, calcium, sodium, and other blood or urine measurements.

Not everyone experiences these effects, and their severity can vary.

Serious Side Effects and Warnings

Liver Problems

Sotorasib can cause hepatotoxicity, including increases in ALT and AST and, in some cases, drug-induced liver injury or hepatitis. Liver-function tests are recommended before treatment, every three weeks during the first three months, and then monthly or as clinically indicated.

Contact your healthcare team promptly if you develop symptoms that may suggest liver problems, such as unusual tiredness, yellowing of the skin or eyes, dark urine, or persistent abdominal discomfort.

Interstitial Lung Disease or Pneumonitis

Sotorasib can cause interstitial lung disease (ILD) or pneumonitis, which can be serious or potentially fatal.

Seek urgent medical attention for new or worsening:

• Shortness of breath
• Cough
• Fever
• Breathing difficulties

If ILD/pneumonitis is suspected, treatment may need to be withheld, and confirmed cases may require permanent discontinuation.

Sotoxen 120mg Precautions

Before starting sotorasib, tell your doctor about your complete medical history and all medicines you use.

Important precautions include:

• Confirming the presence of the KRAS G12C mutation through appropriate testing.
• Informing your doctor about existing liver problems.
• Reporting new or worsening breathing symptoms immediately.
• Keeping all recommended blood tests and medical appointments.
• Informing your healthcare team about previous cancer treatments, particularly immunotherapy.
• Discussing pregnancy or plans to become pregnant with your doctor.
• Avoiding breastfeeding during treatment as advised in the prescribing information.

Sotoxen 120mg Drug Interactions

Sotorasib can interact with several medicines.

The FDA label recommends avoiding proton pump inhibitors (PPIs) and H2-receptor antagonists with sotorasib. If an acid-reducing medicine cannot be avoided, a local antacid may be taken according to the specified timing instructions.

Sotorasib should also generally be avoided with strong CYP3A4 inducers. It can affect certain CYP3A4 and P-glycoprotein (P-gp) substrates, potentially changing their concentrations.

Always give your oncologist a complete list of prescription medicines, over-the-counter products, vitamins, and herbal supplements before starting treatment.

Pregnancy and Breastfeeding

Sotorasib may cause fetal harm based on its pharmacologic properties and available nonclinical information. Women who are pregnant, planning pregnancy, or who could become pregnant should discuss the risks and appropriate contraception with their healthcare provider.

The current prescribing information advises patients not to breastfeed during treatment.

Sotoxen 120mg Tablet Storage

Store Sotoxen according to the instructions on its original packaging.

The FDA-approved sotorasib reference product is stored at 20°C to 25°C (68°F to 77°F), with permitted excursions between 15°C and 30°C. Keep the medicine in its original container and protect it according to the product’s storage instructions.

Keep all medicines out of the reach of children.

Sotoxen 120mg Manufacturer

The manufacturer of Sotoxen 120mg Tablet should be confirmed from the product packaging or official manufacturer documentation before publishing manufacturer-specific information.

For reference, the FDA-approved sotorasib product Lumakras is packaged by Amgen Inc.

Sotoxen 120mg Price in Pakistan

The price of Sotoxen 120mg Tablet in Pakistan may vary depending on availability, importer, pack size, and supplier.

For the latest Sotoxen 120mg price in Pakistan, customers should check the current product listing or contact the pharmacy for updated availability and pricing.

Buy Sotoxen 120mg Tablet in Pakistan

Sotoxen 120mg Tablet is a prescription oncology medicine and should be obtained through a legitimate pharmacy with appropriate medical documentation.

Before purchasing, check the product name, strength, packaging, batch information, expiry date, and manufacturer details. Because sotorasib is a targeted cancer treatment, treatment should remain under the supervision of an oncologist.

Why Choose Impo Medic?

At Impo Medic, we aim to provide reliable information and access to imported medicines while keeping product details clear and easy to understand.

• Product information presented clearly
• Imported medicine availability
• Transparent pricing where available
• Online ordering support
• Assistance with product and availability questions
• Responsible guidance for prescription medicines

FAQs About Sotoxen 120mg Tablet (Sotorasib)

1. What is Sotoxen 120mg used for?

Sotoxen contains sotorasib, which is used for certain cancers with a confirmed KRAS G12C mutation, including specific advanced or metastatic NSCLC and metastatic colorectal cancer cases.

2. What is the active ingredient in Sotoxen 120mg?

The active ingredient is sotorasib 120mg.

3. What is the usual sotorasib dose?

The FDA-labeled recommended dose is 960mg once daily, although the actual treatment plan must be determined by the treating oncologist.

4. Can Sotoxen be taken with food?

Yes. Sotorasib can be taken with or without food and should generally be taken at the same time each day.

5. What are common Sotoxen side effects?

Common side effects include diarrhea, musculoskeletal pain, nausea, fatigue, hepatotoxicity, and cough when sotorasib is used alone for NSCLC.

6. Can Sotoxen affect the liver?

Yes. Sotorasib can cause liver toxicity, which is why regular liver-function monitoring is recommended during treatment.

7. Can Sotoxen cause breathing problems?

Sotorasib can cause ILD or pneumonitis. New or worsening cough, fever, or shortness of breath should be reported to a healthcare professional immediately.

8. Is Sotoxen available in Pakistan?

Availability can vary. Patients should check the current pharmacy listing and confirm the exact product, strength, manufacturer, and packaging before purchase.

Legal & Medical Disclaimer

This information is provided for educational purposes only and does not replace advice from a qualified doctor or oncologist. Sotoxen 120mg Tablet (sotorasib) is a prescription cancer medicine and should only be used according to a healthcare professional’s instructions. Do not start, stop, or change the dose without medical advice.