Description

Safacto AF Injection 500IU – Uses, Dosage, Side Effects & Price in Pakistan

Safacto AF Injection 500IU is a recombinant coagulation Factor VIII medicine used to control and prevent bleeding in people with Hemophilia A, a genetic bleeding disorder caused by insufficient or absent clotting Factor VIII. By replacing the missing clotting factor, Safacto AF helps the blood form clots and reduces the risk of prolonged or excessive bleeding.

Safacto AF 500IU is manufactured by Saman Daroo 8, an Iranian biopharmaceutical company. The product is supplied as a lyophilized powder that is reconstituted before intravenous administration.

What Is Safacto AF Injection 500IU?

Safacto AF Injection 500IU contains recombinant human Coagulation Factor VIII. Factor VIII is an essential protein involved in the normal blood-clotting process. People with Hemophilia A have low or absent Factor VIII activity, which can cause prolonged bleeding after injuries, surgery, or other trauma.

Safacto AF provides replacement Factor VIII to temporarily increase clotting activity and help control bleeding. Recombinant Factor VIII products are produced using biotechnology rather than being obtained directly from donated human plasma.

Product details:

• Brand: Safacto AF
• Strength: 500 IU
• Active ingredient: Recombinant Coagulation Factor VIII
• Dosage form: Lyophilized powder for injection
• Route: Intravenous
• Manufacturer: Saman Daroo 8, Iran
• Main use: Hemophilia A
• Prescription medicine: Yes

Safacto AF Injection 500IU Uses

Safacto AF is primarily used in patients with Hemophilia A who require Factor VIII replacement.

1. Treatment of Bleeding Episodes

Factor VIII replacement can be used to control bleeding episodes in people with Hemophilia A. Treatment helps restore Factor VIII activity so that the body’s clotting process can work more effectively.

2. Prevention of Bleeding

Factor VIII replacement may also be prescribed as regular prophylactic treatment to reduce the frequency of bleeding episodes, particularly in patients with severe Hemophilia A.

3. Before or During Surgery

Patients with Hemophilia A may require Factor VIII replacement around surgical or dental procedures to reduce the risk of excessive bleeding. The dose and duration are determined by the treating hematologist.

How Does Safacto AF Work?

Safacto AF replaces the Factor VIII that is missing or insufficient in people with Hemophilia A.

Factor VIII participates in the coagulation cascade, helping the body generate enough thrombin to form a stable blood clot. When Factor VIII levels are too low, bleeding can continue for longer than normal.

After intravenous administration, recombinant Factor VIII increases Factor VIII activity in the blood. This provides temporary clotting support and helps control or prevent bleeding.

Safacto AF Injection 500IU Dosage

The correct Safacto AF dose is individualized by a hematologist. A 500 IU vial does not mean that every patient should receive 500 IU per dose.

The required amount depends on factors such as:

• Patient’s body weight
• Baseline Factor VIII level
• Desired Factor VIII level
• Type and severity of bleeding
• Location of bleeding
• Whether treatment is for surgery or routine prevention
• Individual response to treatment

For recombinant Factor VIII products, dosing is commonly calculated according to body weight and the desired increase in Factor VIII activity.

Do not change the dose or frequency yourself. Safacto AF should be administered according to the treatment plan provided by a qualified healthcare professional.

How Is Safacto AF 500IU Given?

Safacto AF is intended for intravenous administration after reconstitution.

The powder must be prepared with the appropriate supplied diluent according to the manufacturer’s instructions. The reconstituted product is then administered into a vein by a healthcare professional or by a patient/caregiver who has been properly trained to administer Factor VIII therapy.

Do not inject Safacto AF by another route unless specifically instructed by the treating specialist.

Safacto AF Injection Side Effects

Like other Factor VIII replacement medicines, Safacto AF can cause side effects. The risk varies between patients.

Possible reactions may include:

• Headache
• Fever
• Injection-site discomfort or inflammation
• Dizziness
• Nausea
• Hypersensitivity or allergic reactions
• Chest discomfort or tightness
• Development of Factor VIII inhibitors

A particularly important complication of Factor VIII replacement therapy is the development of inhibitors. These are antibodies that reduce or block the activity of Factor VIII and may make bleeding more difficult to control.

Seek urgent medical attention if symptoms of a serious allergic reaction occur, such as difficulty breathing, swelling of the face or throat, severe rash, or sudden weakness.

Important Precautions

Before receiving Safacto AF, tell your doctor if you:

• Have previously developed Factor VIII inhibitors.
• Have experienced an allergic reaction to a Factor VIII product.
• Have a known allergy to any component of the medicine.
• Are pregnant, planning pregnancy, or breastfeeding.
• Are using other medicines or blood-clotting products.

Patients receiving repeated Factor VIII treatment may require laboratory monitoring of Factor VIII activity and testing for inhibitors when clinically appropriate.

Safacto AF and Factor VIII Inhibitors

Some people with Hemophilia A can develop antibodies called Factor VIII inhibitors after receiving replacement therapy. These antibodies can reduce the effectiveness of treatment.

If bleeding does not respond as expected to the prescribed Factor VIII dose, the treating hematologist may investigate whether an inhibitor is present.

Regular follow-up is therefore important for patients receiving long-term Factor VIII replacement therapy.

Safacto AF Injection Storage

Safacto AF should be stored according to the storage conditions stated on the manufacturer’s packaging and product information.

Do not use the medicine if the vial or packaging appears damaged. The powder should not be used after its expiry date.

Because storage requirements can vary between products and presentations, always check the original package or ask a pharmacist before storing the medicine at home.

Safacto AF Injection 500IU Price in Pakistan

The price of Safacto AF Injection 500IU in Pakistan can vary depending on supplier, import costs, availability, and market conditions.

Because this is a specialty Factor VIII medicine, its availability may be more limited than commonly used medicines. For the latest Safacto AF 500IU price in Pakistan, patients should confirm the current price and availability with the pharmacy before ordering.

Safacto AF Injection 500IU in Pakistan

Safacto AF 500IU may be required by patients with Hemophilia A who need recombinant Factor VIII replacement. Since it is a specialized prescription medicine, it should be obtained from a reliable pharmacy and used only according to a hematologist’s treatment plan.

If your doctor has prescribed Safacto AF Injection 500IU, verify the product name, strength, batch information, expiry date, packaging, and storage conditions before use.

Why Choose Impo Medic?

Impo Medic aims to make access to specialty and imported medicines easier for patients in Pakistan.

When ordering Safacto AF Injection 500IU, customers should look for:

• Genuine and properly packaged medicines
• Correct product strength
• Clear expiry and batch information
• Appropriate storage and handling
• Reliable customer support
• Prescription-based medicine guidance
• Delivery according to applicable requirements

For a specialty medicine such as Factor VIII, authenticity and proper handling are particularly important.

Frequently Asked Questions

What is Safacto AF Injection 500IU used for?

Safacto AF 500IU is a recombinant Factor VIII replacement medicine used to control and prevent bleeding in people with Hemophilia A.

What is the active ingredient in Safacto AF 500IU?

Safacto AF contains recombinant human coagulation Factor VIII. Available product information identifies it as a recombinant Factor VIII product manufactured by Saman Daroo 8.

Is Safacto AF used for Hemophilia A?

Yes. Safacto is a recombinant Factor VIII product developed for patients with Hemophilia A, a condition associated with Factor VIII deficiency.

How is Safacto AF 500IU administered?

It is administered intravenously after the lyophilized powder has been properly reconstituted. Administration should follow the instructions of the treating healthcare professional.

Can Safacto AF be used before surgery?

Factor VIII replacement can be used for perioperative management in patients with Hemophilia A. The dose and duration must be determined by the treating specialist.

Can Safacto AF cause inhibitors?

Yes. Some patients receiving Factor VIII replacement can develop Factor VIII inhibitors, which can reduce the effectiveness of treatment. Appropriate clinical and laboratory monitoring may be required.

Is Safacto AF 500IU available in Pakistan?

Safacto AF 500IU is listed by Pakistani online medicine sellers, although availability can vary. Patients should confirm current stock and authenticity before ordering.

Does Safacto AF cure Hemophilia A?

No. Hemophilia A is a genetic bleeding disorder. Safacto AF provides temporary Factor VIII replacement to help control or prevent bleeding; it does not cure the underlying genetic condition.

Medical Disclaimer

This article is for educational and informational purposes only. Safacto AF Injection 500IU is a prescription Factor VIII replacement medicine and should be used only under the supervision of a qualified healthcare professional. Do not use, stop, or change the dose without medical advice.