Description

Azarest 300mg Tablet (Azacitidine) Uses, Side Effects, Dosage & Price in Pakistan

Azarest 300mg Tablet (Azacitidine) is an oral anticancer medicine containing Azacitidine 300mg. It belongs to a group of medicines called nucleoside metabolic inhibitors and is used as maintenance treatment in certain adults with acute myeloid leukemia (AML) after achieving remission following intensive induction chemotherapy.

Azarest 300mg should only be used under the supervision of a qualified oncologist. The dose, treatment schedule, blood tests, and duration of therapy depend on the patient’s condition and response to treatment.

What Is Azarest 300mg Tablet?

Azarest 300mg Tablet contains Azacitidine, an antineoplastic medicine that affects abnormal DNA and RNA processes in cancer cells. Oral azacitidine is available in 200mg and 300mg strengths.

Azarest is manufactured by Everest Pharmaceuticals Ltd. and is supplied as 300mg film-coated tablets. Product information for Azarest lists a pack containing 14 tablets, with each tablet containing 300mg azacitidine.

Uses of Azarest 300mg Tablet

Azarest 300mg may be prescribed for:

• Maintenance treatment of certain adult patients with acute myeloid leukemia (AML)
• Patients who achieved complete remission (CR) or complete remission with incomplete blood count recovery (CRi) after intensive induction chemotherapy
• Patients who are unable to complete intensive curative therapy or are not candidates for hematopoietic stem cell transplantation, depending on the applicable prescribing indication

The exact indication can vary according to the approved product information in different countries. Your oncologist should determine whether Azarest is appropriate for you.

How Does Azacitidine Work?

Azacitidine is a pyrimidine nucleoside analogue related to cytidine. It enters cells and interferes with DNA and RNA-related processes.

One important action of azacitidine is reducing abnormal DNA methylation. This may help reactivate genes that have been switched off in cancer cells and can interfere with the growth and survival of abnormal cells.

Because azacitidine affects rapidly dividing cells and bone marrow function, regular medical monitoring is important during treatment.

Azarest 300mg Dosage

The commonly recommended oral azacitidine dose is:

300mg once daily on Days 1 to 14 of a 28-day treatment cycle.

After 14 days of treatment, there is generally a 14-day treatment-free period before the next cycle begins. The doctor may reduce the dose, delay treatment, or modify the schedule depending on blood counts, side effects, and treatment response.

Do not change the dose or treatment schedule yourself.

How to Take Azarest 300mg Tablet

• Take Azarest exactly as prescribed by your oncologist.
• Take the tablet at approximately the same time each day.
• It may be taken with or without food.
• Swallow the tablet whole with water.
• Do not crush, chew, split, or dissolve the tablet.
• Your doctor may prescribe an anti-nausea medicine before treatment, particularly during the initial treatment cycles.

If you vomit after taking a dose, do not take another tablet on the same day unless your doctor specifically instructs you to do so.

Side Effects of Azarest 300mg

Like other anticancer medicines, Azarest may cause side effects. Common or important side effects can include:

• Nausea and vomiting
• Diarrhea
• Constipation
• Fatigue or weakness
• Decreased appetite
• Fever
• Headache
• Abdominal discomfort
• Low white blood cell count
• Low platelet count
• Anemia
• Increased risk of infections

Gastrointestinal problems and blood-count abnormalities are important adverse effects associated with oral azacitidine.

Serious Side Effects

Contact your doctor promptly if you develop:

• Fever or signs of infection
• Unusual bleeding or bruising
• Severe weakness or tiredness
• Shortness of breath
• Persistent vomiting or diarrhea
• Severe abdominal symptoms
• Symptoms suggesting a serious infection

Azacitidine can cause neutropenia, thrombocytopenia, and febrile neutropenia, so regular blood-count monitoring is important during treatment.

Precautions Before Taking Azarest

Tell your doctor if you:

• Have liver or kidney problems
• Have a history of severe infections
• Have low blood cell counts
• Are taking other medicines or supplements
• Have experienced an allergic reaction to azacitidine or any ingredient
• Are pregnant, planning pregnancy, or breastfeeding

Your doctor may order complete blood counts and other laboratory tests before and during treatment.

Drug Interactions

Tell your healthcare provider about all prescription medicines, over-the-counter medicines, vitamins, and supplements you take.

Your doctor will determine whether any of your medicines need to be changed or monitored during Azarest treatment.

Do not start a new medicine or supplement without discussing it with your healthcare professional.

Azarest 300mg During Pregnancy and Breastfeeding

Azacitidine may cause harm to an unborn baby. Women who can become pregnant should discuss effective contraception with their healthcare provider during treatment and for the recommended period after treatment.

Men taking azacitidine should also discuss reproductive precautions with their doctor.

Breastfeeding is not recommended during treatment with oral azacitidine according to applicable prescribing information.

Storage of Azarest 300mg Tablet

Store Azarest according to the manufacturer’s instructions.

• Keep the tablets in their original packaging.
• Protect them from excessive heat and moisture.
• Keep the medicine away from children.
• Do not use tablets after the expiry date.
• Follow the product-specific storage instructions on the package.

Manufacturer of Azarest 300mg

Azarest 300mg Tablet is manufactured by Everest Pharmaceuticals Ltd. The manufacturer’s product information identifies Azarest as Azacitidine INN 300mg.

Azarest 300mg Price in Pakistan

The price of Azarest 300mg Tablet in Pakistan can vary depending on availability, supplier, imported stock, and pharmacy or distributor pricing.

For the latest Azarest 300mg price in Pakistan, customers can contact Impo Medic for current availability and pricing.

Buy Azarest 300mg Tablet in Pakistan

If you are looking to buy Azarest 300mg Tablet (Azacitidine) in Pakistan, it is important to purchase from a reliable medicine supplier because this is a specialist oncology medicine.

Impo Medic can help patients and healthcare professionals check the availability of Azarest 300mg and obtain product information before purchase.

Azarest should be used only with a valid prescription and under the supervision of an experienced oncology specialist.

Why Choose Impo Medic?

Impo Medic focuses on providing information and access to specialized medicines, including oncology and other prescription treatments.

When purchasing Azarest 300mg, patients should verify:

• Correct medicine name and strength
• Manufacturer and packaging
• Batch and expiry information
• Storage conditions
• Prescription requirements
• Availability and current price

For Azarest 300mg Tablet price in Pakistan and availability, contact Impo Medic for the latest information.

Frequently Asked Questions (FAQs)

What is Azarest 300mg Tablet used for?

Azarest 300mg contains azacitidine and is used as an oral maintenance treatment for certain adults with AML who have achieved remission following intensive induction chemotherapy, according to the applicable approved indication.

Is Azarest 300mg a chemotherapy medicine?

Yes. Azacitidine is an anticancer medicine that affects DNA and RNA processes and is classified as a nucleoside metabolic inhibitor.

What is the usual dose of Azarest 300mg?

The usual oral azacitidine regimen is 300mg once daily on Days 1–14 of a 28-day cycle, but the treating oncologist may modify the dose or schedule based on the patient’s condition.

Can Azarest 300mg be used instead of injectable azacitidine?

No. Oral azacitidine and injectable azacitidine have different dosing and administration schedules and should not be substituted for one another.

Should Azarest 300mg be taken with food?

Azacitidine tablets can generally be taken with or without food. Try to take the medicine at approximately the same time each day.

Can Azarest 300mg cause low blood counts?

Yes. Azacitidine treatment can cause low levels of white blood cells, platelets, and other blood cells. Regular blood tests are therefore important during treatment.

Can Azarest 300mg cause nausea?

Yes. Nausea and other gastrointestinal side effects can occur with oral azacitidine. Doctors may prescribe anti-nausea treatment, particularly during the first treatment cycles.

Where can I buy Azarest 300mg in Pakistan?

Azarest 300mg should be obtained through a reliable medicine supplier and used only under specialist medical supervision. Contact Impo Medic for current availability and price information.