Description

Adarasib 200mg Tablet (Adagrasib) Uses, Dosage, Side Effects & Price in Pakistan

Adarasib 200mg Tablet contains adagrasib, a targeted cancer medicine used for certain cancers with a specific genetic alteration called the KRAS G12C mutation. It belongs to the KRAS G12C inhibitor class and works by blocking abnormal KRAS signaling that can contribute to cancer-cell growth.

Adarasib 200mg is manufactured by Tongmeng (Lao) Pharmaceutical & Food Co., Ltd. (TLPH). The manufacturer’s product information lists Adarasib as 200mg film-coated tablets supplied in a pack of 120 tablets.

Because adagrasib is a prescription oncology medicine, treatment should only be started under the supervision of an oncologist after appropriate testing confirms the KRAS G12C mutation.

What Is Adarasib 200mg Tablet?

Adarasib 200mg contains adagrasib 200mg, an oral targeted therapy that irreversibly inhibits the KRAS G12C protein.

KRAS normally helps regulate signals involved in cell growth and survival. When the KRAS G12C mutation is present, abnormal signaling can encourage cancer cells to grow and survive. Adagrasib binds to the mutated KRAS G12C protein and keeps it in an inactive state, helping block these signals.

Product Details

• Brand: Adarasib
• Strength: 200mg
• Active ingredient: Adagrasib
• Dosage form: Film-coated tablet
• Route: Oral
• Manufacturer: Tongmeng (Lao) Pharmaceutical & Food Co., Ltd.
• Pack size: 120 tablets
• Drug class: KRAS G12C inhibitor
• Prescription status: Prescription medicine

Adarasib 200mg Uses

Adarasib is used for certain cancers where laboratory testing confirms a KRAS G12C mutation.

1. KRAS G12C-Mutated Non-Small Cell Lung Cancer

Adagrasib is used alone for adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) that has a KRAS G12C mutation and has progressed after at least one previous systemic treatment.

2. KRAS G12C-Mutated Colorectal Cancer

Adagrasib is also used with cetuximab for adults with locally advanced or metastatic colorectal cancer containing a KRAS G12C mutation who have previously received fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.

The appropriate treatment depends on the cancer type, previous therapy, molecular test results and the oncologist’s recommendation.

How Does Adagrasib Work?

Adagrasib is an irreversible KRAS G12C inhibitor. It attaches to the mutated KRAS G12C protein and keeps it inactive.

This blocks KRAS-dependent signaling pathways involved in cancer-cell growth and survival. As a result, adagrasib may help slow the progression of cancers carrying the KRAS G12C mutation.

This mutation-specific action means Adarasib is not suitable for every patient with lung or colorectal cancer. Appropriate molecular testing is important before treatment.

Adarasib 200mg Tablet Dosage

The recommended adagrasib dose is 600mg twice daily. Since each Adarasib tablet contains 200mg, this equals three 200mg tablets per dose, taken twice daily.

Adarasib should generally be:

• Taken twice daily at approximately the same times
• Taken with or without food
• Swallowed whole with water
• Taken exactly as prescribed by the oncologist
• Not crushed, chewed or split

If side effects occur, the doctor may reduce the dose. Recommended dose reductions include 400mg twice daily and then 600mg once daily when necessary.

Do not change the dose yourself.

How to Take Adarasib 200mg Tablet

Swallow the tablets whole with water. Adagrasib can be taken with or without food and should preferably be taken at approximately the same time every day.

If vomiting occurs after taking a dose, do not take another dose. Continue with the next scheduled dose. If a dose is missed by more than four hours, skip it and take the next dose at the usual time.

Adarasib 200mg Tablet (Adagrasib) Side Effects

Adagrasib can cause side effects, some of which may be serious.

Common side effects include:

• Nausea
• Diarrhea
• Vomiting
• Fatigue
• Musculoskeletal pain
• Reduced appetite
• Swelling or edema
• Shortness of breath
• Changes in liver enzymes
• Renal impairment

When used with cetuximab, other reactions such as rash, headache, dry skin, abdominal pain and anemia may occur.

Serious Side Effects

Important risks include:

• Severe gastrointestinal reactions
• QTc interval prolongation
• Hepatotoxicity
• Interstitial lung disease or pneumonitis
• Serious heart-rhythm problems
• Electrolyte abnormalities

Seek medical attention for severe or persistent diarrhea or vomiting, yellowing of the skin or eyes, new breathing problems, fainting, severe weakness, chest symptoms or irregular heartbeat.

Important Precautions

Before starting Adarasib, tell your oncologist if you have:

• Liver disease
• Heart disease
• Abnormal heart rhythm
• Long QT syndrome
• Electrolyte abnormalities
• Lung problems
• Kidney problems
• Previous serious reactions to cancer medicines
• Any allergies

Liver function should be monitored during treatment. The current prescribing information recommends liver tests before treatment and monthly for the first three months, with additional monitoring when needed. ECG and electrolyte monitoring may also be appropriate for patients at risk of QT prolongation.

Adarasib 200mg Tablet Drug Interactions

Adagrasib can interact with several medicines because it affects drug-metabolizing enzymes and transport pathways.

Important interaction groups include:

• Strong CYP3A4 inhibitors and inducers
• Sensitive CYP3A4 substrates
• Sensitive CYP2C9 substrates
• Sensitive CYP2D6 substrates
• P-glycoprotein substrates
• Medicines that can prolong the QT interval

Tell your doctor about all prescription medicines, over-the-counter products, vitamins and herbal supplements before starting Adarasib.

Adarasib and Pregnancy

Adagrasib may cause fetal harm. Women who are pregnant or may become pregnant should discuss the risks with their healthcare professional.

The manufacturer’s information advises against pregnancy during treatment and recommends effective contraception. Breastfeeding should also be avoided during treatment according to current product information.

Adarasib 200mg Storage

Store Adarasib according to the manufacturer’s instructions. The TLPH product information recommends keeping the tablets in their original container with the supplied desiccant and protecting them from moisture.

Keep the medicine away from children and do not use it after the expiry date.

Adarasib 200mg Price in Pakistan

The price and availability of Adarasib 200mg Tablet in Pakistan may vary depending on supplier, product availability, import conditions and market factors.

For the latest Adarasib 200mg price and availability in Pakistan, customers should contact the supplier directly before placing an order. As this is a prescription oncology medicine, it should be used only under the supervision of a qualified healthcare professional.

Buy Adarasib 200mg in Pakistan

Adarasib is a specialized prescription cancer medicine and should only be used under an oncologist’s supervision.

Before purchasing, check:

• Product name and active ingredient
• 200mg strength
• Batch number and expiry date
• Original packaging
• Storage conditions
• Supplier reliability

Because Adarasib targets a specific mutation, patients should not use it simply because they have lung or colorectal cancer. KRAS G12C testing is required for appropriate treatment selection.

Why Choose Impo Medic?

Impo Medic aims to help customers access imported and specialty medicines in Pakistan.

When ordering Adarasib 200mg, customers should look for:

• Genuine imported medicine
• Correct strength and formulation
• Clear batch and expiry information
• Proper packaging
• Appropriate storage and handling
• Reliable product information
• Prescription-based medicine guidance
• Product availability support

For targeted cancer medicines, authenticity and proper handling are especially important.

FAQs About Adarasib 200mg Tablet (Adagrasib)

What is Adarasib 200mg used for?

Adarasib 200mg contains adagrasib, a KRAS G12C inhibitor used for certain advanced or metastatic cancers with a confirmed KRAS G12C mutation, including specific cases of NSCLC and colorectal cancer.

What is the active ingredient in Adarasib 200mg?

The active ingredient is adagrasib 200mg. TLPH lists Adarasib as 200mg film-coated tablets in a 120-tablet pack.

How many Adarasib 200mg tablets are taken daily?

The standard dose is 600mg twice daily, equal to three 200mg tablets per dose and six tablets per day at the standard dose. The oncologist may modify the dose if side effects occur.

Should Adarasib be taken with food?

Adarasib can be taken with or without food. Tablets should be swallowed whole.

Is Adarasib chemotherapy?

No. Adarasib is a targeted KRAS G12C inhibitor, not conventional cytotoxic chemotherapy.

What are the main side effects of Adarasib?

Common effects include nausea, diarrhea, vomiting, fatigue, musculoskeletal pain, reduced appetite and liver enzyme abnormalities. Serious risks include hepatotoxicity, QT prolongation, severe gastrointestinal reactions and pneumonitis.

Does Adarasib work for all lung cancer patients?

No. It is intended for specific patients whose cancer has a confirmed KRAS G12C mutation and meets the relevant treatment criteria.

Where can I check the Adarasib 200mg price in Pakistan?

The price can change according to stock and supplier. Check the current Medicine Waly Dost product listing or contact the pharmacy for the latest price and availability.

Medical Disclaimer

This article is for educational and informational purposes only. Adarasib 200mg is a prescription oncology medicine and should be used only under the supervision of a qualified oncologist. Do not start, stop or change the dose without medical advice.