Description

Alpesib 150 mg Tablet (Alpelisib) – Uses, Dosage, Side Effects & Price in Pakistan

Alpesib 150 mg Tablet (Alpelisib) is a prescription oncology medicine containing alpelisib, a targeted PI3K inhibitor. It is used in combination with fulvestrant for certain adults with hormone receptor-positive (HR-positive), HER2-negative, PIK3CA-mutated advanced or metastatic breast cancer after progression on or following endocrine-based treatment.

Alpelisib primarily inhibits PI3K-alpha, a signaling pathway that can become abnormally active because of PIK3CA mutations. Blocking this pathway can help slow the growth of certain cancer cells.

For patients searching for Alpesib 150 mg Tablet in Pakistan, it is important to understand that the 150 mg strength may be used as part of a prescribed daily dose. The dose should be determined by an oncologist based on the patient’s cancer type, treatment combination, response, and tolerability.

Important: Alpesib is a prescription cancer medicine. It should only be started, adjusted, or discontinued under the supervision of a qualified oncology professional.

Alpesib 150 mg Tablet (Alpelisib) Product Information

Everest Pharmaceuticals’ product information identifies Alpesib 150 mg as an alpelisib product, while independent medicine information also lists Everest Pharmaceuticals Ltd. as the manufacturer.

What Is Alpesib 150 mg Tablet?

Alpesib contains alpelisib, a targeted anticancer medicine belonging to the PI3K inhibitor class.

Unlike medicines that broadly affect rapidly dividing cells, alpelisib targets the PI3K signaling pathway, particularly PI3K-alpha. This pathway can become overactive in cancers carrying certain PIK3CA mutations.

Because treatment is linked to the presence of a specific mutation, patients may require validated testing to determine whether their cancer has a relevant PIK3CA mutation.

What are the Uses of Alpesib 150 mg?

Alpelisib is used for specific patients with HR-positive, HER2-negative, PIK3CA-mutated advanced or metastatic breast cancer.

In the FDA-approved indication, it is used in combination with fulvestrant following progression on or after an endocrine-based treatment.

Whether this treatment is appropriate depends on factors such as:

• Breast cancer subtype.
• Disease stage.
• PIK3CA mutation status.
• Previous endocrine treatment.
• Previous cancer therapies.
• Overall health.
• Blood glucose and metabolic health.
• Other medicines being taken.

Your oncologist should determine whether alpelisib is appropriate for your individual treatment plan.

How Does Alpelisib Work?

Alpelisib inhibits PI3K-alpha, an enzyme involved in signaling pathways that regulate cell growth, survival, and metabolism.

Certain mutations in the PIK3CA gene can activate this pathway abnormally. By inhibiting PI3K-alpha, alpelisib can interfere with signaling that supports the growth and survival of cancer cells carrying these mutations.

This targeted mechanism is why mutation testing can be an important part of selecting appropriate patients for treatment.

Alpesib 150 mg Dosage

The appropriate dose is determined by the prescribing oncologist.

For the FDA-approved alpelisib regimen for PIK3CA-mutated HR-positive, HER2-negative advanced or metastatic breast cancer, the recommended dose is 300 mg once daily with food, which corresponds to two 150 mg tablets.

This does not mean every patient should take two tablets without medical advice.

Dose interruption or reduction may be required if significant adverse reactions occur.

How to Take Alpesib 150 mg Tablet

Alpelisib should be taken exactly as prescribed.

General administration instructions include:

• Take it with food.
• Take it at approximately the same time each day.
• Swallow the tablet whole.
• Do not crush, chew, or split the tablet unless specifically instructed.
• Do not change the prescribed number of tablets yourself.

The official product information recommends taking alpelisib with food.

Alpesib 150 mg Tablet Side Effects

Alpelisib can cause side effects, and some require close medical monitoring.

Reported adverse reactions include:

• Hyperglycemia (high blood sugar).
• Diarrhea.
• Rash.
• Nausea.
• Decreased appetite.
• Weight loss.
• Fatigue.
• Stomatitis or mouth sores.
• Vomiting.
• Changes in blood-test results.

The severity varies between patients, and some reactions may require treatment interruption or dose adjustment.

Alpelisib and High Blood Sugar

One of the most important safety considerations with alpelisib is hyperglycemia.

Because PI3K signaling is involved in glucose metabolism, alpelisib can increase blood glucose levels. Your healthcare team may check fasting blood glucose and HbA1c before and during treatment.

Tell your healthcare professional if you develop symptoms such as:

• Excessive thirst.
• Frequent urination.
• Unusual weakness.
• Increased hunger.
• Blurred vision.

Severe or uncontrolled hyperglycemia requires prompt medical attention.

Alpesib 150 mg and Diarrhea

Diarrhea is a commonly reported adverse reaction with alpelisib.

If diarrhea develops, your healthcare professional may recommend an appropriate antidiarrheal treatment and increased fluid intake. Persistent or severe diarrhea can lead to dehydration and may require treatment adjustment.

Contact your healthcare team if diarrhea is severe, persistent, or accompanied by signs of dehydration.

Alpesib 150 mg Tablet and Skin Reactions

Alpelisib can cause skin reactions, including potentially serious cutaneous adverse reactions.

Contact your healthcare professional promptly if you develop:

• Widespread rash.
• Blistering.
• Skin peeling.
• Painful skin lesions.
• Swelling.
• Fever together with a significant rash.

Serious skin reactions may require immediate treatment and permanent discontinuation in confirmed cases.

Alpesib 150 mg and Lung Problems

Rare but serious lung inflammation, including pneumonitis, can occur with alpelisib.

Report new or worsening:

• Cough.
• Shortness of breath.
• Difficulty breathing.
• Chest discomfort.

Confirmed pneumonitis requires appropriate medical management, and official prescribing information recommends permanent discontinuation when confirmed.

Who Should Not Use Alpesib Without Medical Advice?

Before starting treatment, tell your oncologist about:

• Diabetes or high blood sugar.
• Previous severe skin reactions.
• Lung disease.
• Liver or kidney problems.
• Current medicines.
• Allergies.
• Pregnancy or plans to become pregnant.

Alpelisib is contraindicated in patients with severe hypersensitivity to the medicine or its components.

Alpesib 150 mg Tablet Treatment Schedule

For the approved breast-cancer use of alpelisib, the recommended dose is generally 300 mg once daily with food, meaning two 150 mg tablets when this strength is prescribed. Treatment is continued according to the oncologist’s plan and in combination with fulvestrant.

The treatment may need to be interrupted or reduced if significant adverse reactions occur. Patients should never change the number of tablets themselves.

What If You Miss an Alpesib 150 mg Dose?

If a dose is missed, alpelisib can generally be taken with food within 9 hours of the usual dosing time.

If more than 9 hours have passed, skip that day’s dose and take the next dose at the usual time.

Do not take two doses together to compensate for a missed dose.

If you frequently forget doses, speak with your healthcare team about ways to make your medication routine easier to follow.

What If You Vomit After Taking Alpelisib?

If vomiting occurs after taking the medicine, do not take another dose on the same day.

Resume the normal dosing schedule the following day at the usual time.

If vomiting is persistent or you cannot keep food or fluids down, contact your healthcare professional.

Alpesib 150 mg Tablet Dose Adjustments

Your oncologist may temporarily interrupt treatment or reduce the dose if certain adverse reactions become significant.

Dose management may be required for problems such as:

• Severe hyperglycemia.
• Significant diarrhea or colitis.
• Serious skin reactions.
• Pneumonitis.
• Other clinically important adverse effects.

The exact dose adjustment depends on the severity of the reaction and how quickly it improves.

Never reduce or increase your dose without your oncology team’s instructions.

Blood Sugar Monitoring During Alpelisib Treatment

High blood sugar (hyperglycemia) is one of the most important adverse effects associated with alpelisib.

Before treatment, your healthcare professional may check:

• Fasting plasma glucose.
• HbA1c.
• Other relevant metabolic parameters.

Blood glucose should then be monitored regularly during treatment. Patients with existing risk factors for hyperglycemia may require closer monitoring.

Tell your healthcare provider if you experience:

• Excessive thirst.
• Frequent urination.
• Unusual tiredness.
• Increased hunger.
• Blurred vision.

Severe hyperglycemia can require urgent medical management.

Who Is at Higher Risk of High Blood Sugar?

Patients with existing diabetes, prediabetes, obesity, or other metabolic risk factors may require particularly careful monitoring.

This does not automatically mean that alpelisib cannot be used, but your oncologist may need to assess your glucose control before starting treatment and monitor it more closely during therapy.

Do not start diabetes medication or change an existing diabetes treatment without medical guidance.

Alpesib 150 mg Tablet and Diarrhea

Diarrhea is a relatively common adverse effect of alpelisib and can sometimes become serious.

If diarrhea develops, your healthcare team may recommend appropriate antidiarrheal treatment and increased fluid intake.

Contact your healthcare professional if diarrhea:

• Becomes severe.
• Continues despite treatment.
• Causes dizziness or weakness.
• Reduces your ability to drink fluids.
• Occurs with abdominal pain or blood/mucus in the stool.

Persistent diarrhea can sometimes be associated with colitis, which requires medical evaluation.

Alpesib 150 mg Tablet and Skin Rash

Skin reactions can occur during treatment with alpelisib.

A mild rash may be managed by your healthcare team, but widespread rash, blistering, peeling skin, painful skin lesions, or rash accompanied by fever can indicate a serious reaction.

Contact your healthcare provider immediately if these symptoms occur. Official prescribing information specifically warns about severe cutaneous adverse reactions.

Alpelisib and Lung Problems

Alpelisib can rarely cause pneumonitis, an inflammatory condition affecting the lungs.

Contact your healthcare team promptly if you develop:

• New cough.
• Shortness of breath.
• Difficulty breathing.
• Unexplained chest discomfort.

New respiratory symptoms should not simply be assumed to be a normal medicine side effect. Your doctor may need to investigate the cause.

Alpesib 150 mg Tablet Drug Interactions

Alpelisib can interact with certain medicines.

The prescribing information recommends avoiding strong CYP3A4 inducers, because they can reduce alpelisib exposure and potentially decrease its effectiveness. It also recommends avoiding BCRP inhibitors where possible because they may increase alpelisib exposure and the risk of adverse reactions.

Before starting treatment, tell your doctor or pharmacist about:

• Prescription medicines.
• Painkillers.
• Antibiotics.
• Antifungal medicines.
• Diabetes medicines.
• Vitamins.
• Herbal supplements.
• Other cancer medicines.

Do not stop another prescribed medicine simply because you are starting alpelisib. Ask your healthcare professional first.

Alpesib 150 mg Tablet With Food

Alpelisib should be taken with food, preferably at approximately the same time each day.

Taking it consistently with food is part of the recommended administration instructions.

The tablet should generally be swallowed whole. Do not chew, crush, or split it unless your healthcare professional provides specific instructions for your product.

Alpelisib During Pregnancy

Alpelisib can cause fetal harm based on its mechanism and animal reproductive data.

Patients who can become pregnant should discuss effective contraception with their healthcare professional. Current prescribing information recommends contraception during treatment and for 1 week after the last dose.

If pregnancy occurs while taking alpelisib, contact your healthcare professional promptly.

Alpelisib and Breastfeeding

Breastfeeding is not recommended during alpelisib treatment and for 1 week after the final dose, according to current prescribing information.

Discuss your individual situation with your oncologist before starting treatment.

Can Alpelisib Affect Fertility?

Based on animal studies, alpelisib may impair fertility in both males and females of reproductive potential.

If fertility is an important concern, discuss available options with your oncologist before treatment begins.

How Should Alpesib 150 mg Tablet Be Stored?

Follow the storage instructions supplied with the specific product packaging you receive.

For alpelisib tablets, current U.S. product instructions specify storage at 20°C to 25°C (68°F to 77°F).

General precautions include:

• Keep the medicine in its original packaging.
• Protect it from unsuitable temperatures and moisture.
• Keep it away from children.
• Do not use damaged tablets.
• Check the expiry date before use.

For an imported product, always prioritize the storage instructions printed on the actual pack and accompanying leaflet.

Why Regular Follow-Up Matters

Treatment with alpelisib is not simply about taking a tablet every day. Your oncology team may need to monitor:

Blood glucose → HbA1c → treatment tolerance → skin symptoms → gastrointestinal symptoms → respiratory symptoms → other relevant laboratory results.

Regular follow-up allows your doctor to identify complications early and decide whether treatment should continue unchanged, be interrupted, or require a dose adjustment.

Alpesib 150 mg Tablet Price in Pakistan

The Alpesib 150 mg price in Pakistan may vary depending on pack size, supplier, import costs, exchange rates, and current availability.

Because Alpesib is a specialized oncology medicine, stock and pricing may change. For the latest Alpesib 150 mg Tablet price and availability in Pakistan, customers can contact ImpoMedic before placing an order.

Price and availability notice: Medicine prices can change, so confirm the current price and stock before ordering.

Buy Alpesib 150 mg Tablet online in Pakistan

If an oncologist has prescribed alpelisib, choosing the correct strength and product is important.

Before ordering, confirm:

• Product name and strength.
• Active ingredient.
• Pack size.
• Manufacturer.
• Batch number.
• Expiry date.
• Packaging condition.
• Storage requirements.

Since this is a prescription oncology medicine, customers should have a valid prescription and follow the treatment plan provided by their healthcare professional.

For current Alpesib 150 mg Tablet availability in Pakistan, contact ImpoMedic for product and ordering information.

Why Choose ImpoMedic?

When purchasing a specialized cancer medicine, customers need reliable product information as well as availability.

Clear Product Information

ImpoMedic provides information about the medicine’s active ingredient, strength, uses, dosage, precautions, side effects, and storage so customers can make informed decisions alongside their healthcare professional’s advice.

Specialty Medicine Support

Alpelisib is a targeted oncology medicine. ImpoMedic helps customers check the current availability and pricing of specialty medicines before ordering.

Product Verification

Customers should be able to check important product details such as the manufacturer, batch number, expiry date, strength, and packaging when receiving their medicine.

Convenient Delivery

ImpoMedic provides delivery support for customers in Pakistan, making access to specialty and imported medicines more convenient.

Responsible Medical Information

Our product information is designed to answer common customer questions without replacing professional medical advice. Treatment decisions should always remain with the patient’s oncologist.

Customer Assistance

For product availability, pricing, and ordering questions, customers can contact the ImpoMedic team.

Alpesib 150 mg Tablet Manufacturer

Alpesib 150 mg is an alpelisib product listed by Everest Pharmaceuticals Ltd. Everest’s product information identifies Alpesib as containing alpelisib 150 mg.

For the exact product you receive, always check the physical packaging for:

• Manufacturer details.
• Country of origin.
• Batch number.
• Manufacturing date.
• Expiry date.
• Registration or product information where applicable.

This is particularly important for imported medicines because packaging and market presentation can differ.

Alpesib 150 mg Tablet (Alpelisib) Storage

Follow the storage instructions provided with the specific product packaging.

For alpelisib tablets, official U.S. product information specifies storage at 20°C–25°C (68°F–77°F), with permitted temperature excursions according to the labeling.

For customers receiving an imported product:

• Keep the tablets in their original packaging.
• Protect them from excessive heat and moisture.
• Keep the medicine away from children.
• Check the expiry date before use.
• Do not use tablets from damaged packaging.
• Follow the storage instructions printed on the actual package.

Important Safety Information

Alpelisib requires medical supervision because some adverse reactions can be clinically significant.

Important risks include:

• Hyperglycemia
• Severe skin reactions
• Diarrhea or colitis
• Pneumonitis
• Hypersensitivity reactions

Blood glucose monitoring is particularly important because increased blood sugar is one of the characteristic risks associated with alpelisib.

Seek medical advice promptly if you experience severe or persistent diarrhea, significant rash or skin peeling, new breathing difficulties, or symptoms of severe hyperglycemia.

Do not discontinue treatment or change the dose without speaking with your oncology team.

Alpesib 150 mg Tablet and PIK3CA Mutation Testing

One of the most important aspects of alpelisib treatment is PIK3CA mutation status.

For the relevant approved breast-cancer indication, treatment is intended for patients whose tumors have an appropriate PIK3CA mutation. A validated diagnostic test may therefore be used to identify eligible patients.

This means that simply having HR-positive breast cancer does not automatically mean that alpelisib is appropriate.

Your oncologist determines whether mutation testing and this treatment are suitable for your individual case.

Alpelisib With Fulvestrant

For the relevant advanced or metastatic breast-cancer indication, alpelisib is used in combination with fulvestrant.

The combination is intended for patients meeting the appropriate clinical and molecular criteria, including HR-positive, HER2-negative disease with a PIK3CA mutation.

The complete treatment plan should therefore be determined by an oncologist rather than by the tablet strength alone.

Order Alpesib 150 mg Tablet from ImpoMedic

Looking for Alpesib 150 mg Tablet (Alpelisib) in Pakistan?

Contact ImpoMedic to check:

• Current availability.
• Latest price.
• Pack information.
• Ordering details.
• Delivery options.

Before ordering, make sure the product and strength match your prescription.

Alpesib 150 mg Tablet (Alpelisib) should only be used under appropriate medical supervision.

FAQs about Alpesib 150 mg Tablet (Alpelisib)

1. What is Alpesib 150 mg Tablet (Alpelisib) used for?

Alpesib contains alpelisib, a targeted cancer medicine used with fulvestrant for certain adults with PIK3CA-mutated, HR-positive, HER2-negative advanced or metastatic breast cancer.

2. How does Alpesib 150 mg Tablet work?

Alpelisib blocks the PI3K-alpha pathway, which can become overactive in cancers with certain PIK3CA mutations. Blocking this pathway may help slow the growth of cancer cells.

3. What is the usual dose of Alpelisib?

For the relevant approved breast cancer indication, the recommended dose is generally 300 mg once daily with food. With 150 mg tablets, this corresponds to two tablets. The exact dose must be prescribed by an oncologist.

4. What are the common side effects of Alpesib?

Common side effects may include high blood sugar, diarrhea, rash, nausea, decreased appetite, fatigue, vomiting, and weight loss. Your doctor will advise you about monitoring and management.

5. Can Alpesib cause high blood sugar?

Yes. Hyperglycemia is an important potential side effect of alpelisib. Blood glucose and HbA1c may be checked before and during treatment.

6. How should Alpesib 150 mg Tablet be taken?

Alpelisib should generally be taken with food, at approximately the same time each day, exactly as prescribed. Tablets should be swallowed whole unless your healthcare professional gives different instructions.

7. What should I do if I miss a dose?

If a dose is missed, follow the instructions provided by your healthcare professional. Under current prescribing information, a missed dose may generally be taken within 9 hours of the usual time; after that, the missed dose should be skipped.

8. Can I take Alpesib during pregnancy?

Alpelisib may cause fetal harm. Patients who can become pregnant should discuss effective contraception with their healthcare professional before and during treatment.

9. Can I breastfeed while taking Alpesib?

Breastfeeding is not recommended during alpelisib treatment and for 1 week after the final dose according to current prescribing information.

10. What is the price of Alpesib 150 mg in Pakistan?

The Alpesib 150 mg price in Pakistan can vary according to pack size, supplier, import costs, and availability. Contact ImpoMedic for the latest price and stock information.

11. Where can I buy Alpesib 150 mg Tablet in Pakistan?

If you have a prescription for alpelisib, you can contact ImpoMedic to check the current availability, price, and ordering information for Alpesib 150 mg in Pakistan.

12. Who manufactures Alpesib 150 mg Tablet?

Alpesib 150 mg Tablet (Alpelisib) is listed as an alpelisib product by Everest Pharmaceuticals Ltd. Always check the physical packaging for the exact manufacturer, country of origin, batch number, and expiry date.