Description

Zavicefta 2g/0.5g Vial (Ceftazidime/Avibactam) Uses, Dosage, Side Effects & Price in Pakistan

Zavicefta Injection 2g/0.5g Vial is a prescription antibiotic containing two active ingredients: ceftazidime 2 g and avibactam 0.5 g. It is used to treat certain serious bacterial infections, especially infections caused by aerobic Gram-negative bacteria when treatment options may be limited. Zavicefta is supplied as a powder that is prepared and given through an intravenous (IV) infusion by a healthcare professional.

Because it is a specialized antibiotic, Zavicefta should only be used when prescribed by a qualified doctor. Appropriate antibiotic selection is important to reduce unnecessary antibiotic use and resistance.

What Is Zavicefta 2g/0.5g Vial?

Zavicefta contains ceftazidime, a cephalosporin antibiotic, and avibactam, a beta-lactamase inhibitor.

Ceftazidime works by interfering with bacterial cell-wall formation. Avibactam helps protect ceftazidime from certain beta-lactamase enzymes produced by bacteria. This combination can therefore remain active against some bacteria that may be resistant to certain other beta-lactam antibiotics.

Each vial contains ceftazidime equivalent to 2 g and avibactam equivalent to 0.5 g, in a fixed 4:1 combination. The vial is a powder for concentrate for solution for infusion.

Zavicefta Injection Uses

The main Zavicefta Injection Uses include certain serious infections such as:

• Complicated intra-abdominal infections
• Complicated urinary tract infections, including pyelonephritis
• Hospital-acquired pneumonia
• Ventilator-associated pneumonia
• Certain bloodstream infections associated with these infections
• Serious aerobic Gram-negative infections where treatment options are limited

For complicated intra-abdominal infections, Zavicefta may be used with metronidazole when anaerobic bacteria are known or suspected. If Gram-positive bacteria are involved or suspected, an appropriate antibacterial medicine may also be required.

The doctor may consider laboratory testing and the patient’s clinical condition when deciding whether this antibiotic is appropriate.

How Does Zavicefta Work?

The two ingredients work together in different ways.

Ceftazidime attacks bacteria by interfering with the formation of their cell wall. This can prevent susceptible bacteria from growing and surviving.

Avibactam blocks certain beta-lactamase enzymes that some bacteria produce to protect themselves from beta-lactam antibiotics. By inhibiting these enzymes, avibactam can help preserve the antibacterial activity of ceftazidime against certain resistant organisms.

However, Zavicefta is not effective against every bacterial infection. Its use should be based on medical assessment and, when appropriate, microbiological susceptibility results.

Zavicefta 2g/0.5g Dosage

For adults with creatinine clearance above 50 mL/min, the recommended dose for several approved indications is 2 g/0.5 g every 8 hours, given as an IV infusion over approximately 2 hours.

Treatment duration depends on the infection:

• Complicated intra-abdominal infection: usually 5–14 days
• Complicated urinary tract infection: usually 5–10 days
• Hospital-acquired or ventilator-associated pneumonia: usually 7–14 days

The exact treatment duration is decided by the treating doctor according to the infection, its severity and the patient’s response.

Zavicefta Dose in Kidney Problems

Zavicefta dosing needs adjustment in patients with reduced kidney function. For example, adults with creatinine clearance between 31 and 50 mL/min may receive a lower dose than patients with normal renal function. Further adjustments are required at lower levels of kidney function.

Therefore, patients should never change their Zavicefta dose themselves.

How Is Zavicefta Given?

Zavicefta is administered intravenously. The powder must be properly reconstituted and diluted before administration, and the infusion is given over approximately 120 minutes according to the product information.

Preparation and administration should be performed by trained healthcare professionals using appropriate aseptic procedures. Each vial is intended for single use.

Zavicefta 2g/0.5g Side Effects

Like other antibiotics, Zavicefta may cause side effects. Possible Zavicefta 2g/0.5g side effects include:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness
• Changes in liver enzyme levels
• Infusion-related or injection-site reactions

Serious allergic or hypersensitivity reactions can also occur. Zavicefta should not be used in people with a known severe hypersensitivity to ceftazidime, other cephalosporins, or certain severe reactions to other beta-lactam antibiotics.

Severe Diarrhea

As with other antibacterial medicines, persistent or severe diarrhea during or after treatment can sometimes be associated with Clostridioides difficile infection.

If diarrhea becomes severe, persistent or contains blood, contact a healthcare professional rather than treating it yourself.

Zavicefta Precautions

Before receiving Zavicefta, tell your doctor if you have:

• Previous allergy to cephalosporins
• Severe allergy to penicillins or other beta-lactam antibiotics
• Kidney disease
• Previous antibiotic-associated diarrhea
• Other medicines or supplements that you are taking

Kidney function is particularly important because the dose may need to be adjusted when renal function is reduced.

Zavicefta also contains approximately 146 mg of sodium per vial, which may be relevant for people who need to control their sodium intake.

Zavicefta Drug Interactions

Tell your doctor about all medicines you use before starting treatment.

The current product information specifically states that probenecid is not recommended with Zavicefta, as it may affect the elimination of avibactam.

Your healthcare professional should review your medication list before treatment to identify any relevant interactions.

Zavicefta Manufacturer

The current UK product information lists Pfizer Limited as the marketing authorisation holder for Zavicefta.

When buying an imported medicine, check the actual packaging for the manufacturer, batch number, expiry date, strength and packaging condition. Manufacturer details can be important when verifying a specialized medicine.

Zavicefta 2g/0.5g Price in Pakistan

The Zavicefta 2g/0.5g Price in Pakistan can vary depending on availability, supplier, import costs and stock status. Specialized imported antibiotics may have changing prices because of supply and import factors.

Before purchasing, confirm the exact product name, strength, manufacturer, expiry date and packaging.

Buy Zavicefta 2g/0.5g in Pakistan

If you want to Buy Zavicefta 2g/0.5g in Pakistan, contact a reliable medicine supplier to confirm current stock, price and delivery information.

Because Zavicefta is a prescription IV antibiotic, it should only be purchased and administered according to a qualified healthcare professional’s prescription and treatment plan. It should not be used for viral infections such as common flu or cold.

Important: Antibiotic treatment should be completed according to the doctor’s instructions. Do not start, stop or change Zavicefta treatment without medical advice.

Why Choose ImpoMedic?

ImpoMedic helps customers in Pakistan access specialized and imported medicines with clear product information and ordering support. Customers can contact the team to confirm Zavicefta 2g/0.5g price, availability, product details and delivery options before placing an order.

The focus is on proper product handling, secure packaging and reliable delivery support for specialty

FAQs About Zavicefta Injection 2g/0.5g Vial

1. What is Zavicefta 2g/0.5g Vial used for?

Zavicefta contains ceftazidime and avibactam and is used to treat certain serious bacterial infections, including complicated urinary tract infections, complicated intra-abdominal infections, and hospital-acquired pneumonia.

2. How is Zavicefta 2g/0.5g given?

Zavicefta is given through an intravenous (IV) infusion by a qualified healthcare professional. It should not be self-administered.

3. What are the common Zavicefta 2g/0.5g side effects?

Possible side effects include diarrhea, nausea, vomiting, headache, dizziness, changes in liver enzymes and infusion-related reactions.

4. Does Zavicefta require kidney dose adjustment?

Yes. Patients with reduced kidney function may need a lower dose or different dosing interval. A healthcare professional should determine the appropriate dose after assessing kidney function.

5. Can Zavicefta be used for every bacterial infection?

No. Zavicefta is active against specific susceptible bacteria and is not appropriate for every infection. Doctors may use laboratory testing to determine whether the bacteria are susceptible to the medicine.

6. What is the Zavicefta 2g/0.5g Price in Pakistan?

The price can vary depending on availability, supplier, import costs and stock. Contact ImpoMedic for the current price and availability.

7. Can I Buy Zavicefta 2g/0.5g in Pakistan?

You can contact ImpoMedic to check the availability, price and delivery options. As Zavicefta is a prescription IV antibiotic, it should only be used according to a doctor’s prescription.

8. Who should administer Zavicefta?

Zavicefta should be prepared and administered by a trained healthcare professional. The vial requires proper reconstitution and dilution before IV infusion.

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