Description

Xtandi 40mg Capsule (Enzalutamide) – Uses, Dosage, Side Effects & Price in Pakistan

Xtandi 40mg Capsule (Enzalutamide) is a prescription medicine used in the treatment of certain types of advanced prostate cancer. It contains enzalutamide, an androgen receptor signalling inhibitor that works by blocking the effects of male hormones that can support prostate cancer growth. Xtandi may be used alone or with androgen deprivation therapy (ADT), depending on the patient’s specific prostate cancer condition.

Because enzalutamide is a specialist cancer medicine, treatment should be started and monitored by a doctor experienced in managing prostate cancer.

What Is Xtandi 40mg Capsule?

Xtandi contains enzalutamide, which belongs to a group of medicines called androgen receptor inhibitors.

Prostate cancer cells can use male hormones called androgens, including testosterone, to grow. Enzalutamide works by interfering with androgen receptor signalling at several stages. It prevents androgen from activating the receptor and reduces the receptor’s movement into the cell nucleus, helping reduce signals that support prostate cancer growth.

Each Xtandi capsule contains 40mg of enzalutamide. The usual total daily dose is 160mg, meaning four 40mg capsules are taken once daily when the standard dose is prescribed.

Xtandi 40mg Uses

The main Xtandi 40mg Uses are related to advanced or high-risk prostate cancer.

Current product information lists enzalutamide for several prostate cancer settings, including:

• High-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in appropriate adult men
• Metastatic hormone-sensitive prostate cancer
• High-risk non-metastatic castration-resistant prostate cancer
• Metastatic castration-resistant prostate cancer in certain treatment situations

The exact treatment approach depends on the stage of cancer, previous treatment, hormone sensitivity and whether the cancer has spread.

Xtandi is not suitable for every prostate cancer patient. The oncologist decides whether enzalutamide is appropriate based on the patient’s medical history and cancer characteristics.

How Does Enzalutamide Work?

Enzalutamide targets the androgen receptor pathway.

Some prostate cancer cells depend on androgen signalling to grow. Enzalutamide competitively blocks androgen from binding to the androgen receptor and interferes with receptor activity inside cancer cells. This reduces androgen receptor signalling that can contribute to prostate cancer progression.

For many patients with castration-resistant or metastatic hormone-sensitive prostate cancer, enzalutamide is used alongside androgen deprivation therapy unless surgical castration has already been performed.

Xtandi 40mg Dosage

The standard recommended dose of enzalutamide is 160mg once daily, which equals four 40mg capsules.

The capsules should be swallowed whole with sufficient water. They should not be chewed, opened or crushed. Xtandi can generally be taken with or without food.

The doctor may temporarily stop treatment or reduce the dose if a patient develops significant toxicity or an intolerable adverse reaction. Dose changes should only be made by the treating healthcare professional.

Patients should not increase or reduce their Xtandi dose themselves.

Missed Dose

If you miss your usual dose, take the prescribed dose as soon as reasonably possible on the same day. If you miss the dose for the entire day, resume your normal dose the following day. Do not take extra capsules to make up for a missed dose.

Xtandi 40mg Side Effects

Like other cancer medicines, Xtandi 40mg side effects can occur. Commonly reported effects include:

• Tiredness or weakness
• Hot flushes
• Headache
• High blood pressure
• Falls
• Fractures

Other adverse effects can occur depending on the patient’s health and treatment combination.

Seizure Risk

Enzalutamide has been associated with seizures. The risk may be more important in people who already have factors that can increase seizure risk. Patients should tell their doctor about any previous seizures or neurological conditions before starting treatment. (emc)

Rare cases of posterior reversible encephalopathy syndrome (PRES) have also been reported. Symptoms can include headache, confusion, seizures or visual disturbances and require urgent medical assessment.

Xtandi 40mg Precautions

Tell your doctor before using Xtandi if you have:

• A history of seizures
• Conditions that may increase seizure risk
• Heart or cardiovascular problems
• High blood pressure
• Severe kidney problems
• Liver disease
• Previous serious medicine allergies

Enzalutamide has also been associated with ischemic heart disease in clinical studies. Patients with cardiovascular risk factors should be appropriately monitored during treatment.

Women who are pregnant or may become pregnant should not take or handle damaged enzalutamide capsules because the medicine may harm a developing fetus.

Xtandi 40mg Drug Interactions

Enzalutamide can affect the activity of several drug-metabolising enzymes and may therefore change the effects of other medicines.

Some medicines can also affect enzalutamide levels. Strong CYP2C8 inhibitors, such as gemfibrozil, should generally be avoided where possible. If a strong CYP2C8 inhibitor must be used, the enzalutamide dose may need to be reduced under medical supervision.

Tell your doctor about all prescription medicines, over-the-counter medicines and supplements you use before starting Xtandi.

Xtandi 40mg Storage

Store Xtandi according to the instructions supplied with the product and keep it away from children.

Do not use capsules after their expiry date. Patients and caregivers should follow the product’s handling and disposal instructions, particularly if a capsule is damaged.

Xtandi Manufacturer

Xtandi is associated with Astellas Pharma, the company responsible for the Xtandi brand. Current UK product information for enzalutamide lists Astellas Pharma Ltd. as the marketing authorisation holder for Enzalutamide Astellas.

When purchasing an imported Xtandi product, check the packaging for the manufacturer, batch number, expiry date, strength and product integrity.

Xtandi 40mg Price in Pakistan

The Xtandi 40mg Price in Pakistan can vary depending on supplier, import costs, availability and current stock. Specialty oncology medicines may have changing prices because they often require controlled supply and specialist handling.

Before purchasing, confirm the exact strength, formulation, manufacturer and expiry information.

Buy Xtandi 40mg Capsule in Pakistan

If you want to Buy Xtandi 40mg Capsule in Pakistan, contact a reliable medicine supplier to confirm current availability, price and delivery details.

Xtandi is a prescription cancer medicine and should only be used according to an oncologist’s treatment plan. Do not start, stop or change enzalutamide treatment without medical advice.

For imported oncology medicines, customers should also verify the 40mg strength, manufacturer, batch number, expiry date and packaging before accepting an order.

Why Choose ImpoMedic?

ImpoMedic helps customers find specialized and imported medicines with clear product information and convenient order support. For Xtandi 40mg Capsule (Enzalutamide), customers can contact ImpoMedic to check the current price, availability and delivery options in Pakistan.

Before ordering, customers can confirm important product details such as the 40mg strength, manufacturer, batch number, expiry date and packaging condition. For specialty cancer medicines, checking these details is especially important.

If you are looking to buy Xtandi 40mg in Pakistan, ImpoMedic can help you check the latest availability and product information before placing an order.

Frequently Asked Questions

1. What is Xtandi 40mg Capsule used for?

Xtandi contains enzalutamide and is used to treat certain types of advanced prostate cancer. It may be used alone or with androgen deprivation therapy depending on the patient’s condition and treatment plan.

2. What is the usual Xtandi 40mg dosage?

The usual total dose of enzalutamide is 160mg once daily, which equals four 40mg capsules or tablets. The exact treatment should always follow the oncologist’s prescription.

3. What are the common Xtandi 40mg side effects?

Common side effects can include tiredness, hot flushes, high blood pressure, headache, falls and fractures. Seizures and other serious reactions can also occur.

4. Can Xtandi cause seizures?

Yes. Seizures have been reported with enzalutamide treatment. Patients with a history or increased risk of seizures should tell their doctor before starting treatment.

5. Can Xtandi 40mg be taken with food?

Yes. Enzalutamide can generally be taken with or without food. Capsules should be swallowed whole and should not be opened, chewed or crushed.

6. Who manufactures Xtandi?

Xtandi is an enzalutamide product associated with Astellas Pharma. For imported products, check the actual packaging for the manufacturer and product details.

7. What is the Xtandi 40mg Price in Pakistan?

The Xtandi 40mg Price in Pakistan can vary depending on availability, supplier, import costs and stock. Contact ImpoMedic for the current price and availability.

8. Can I Buy Xtandi 40mg Capsule in Pakistan?

Yes, you can contact ImpoMedic to check current availability, price and delivery options. Xtandi is a prescription cancer medicine and should only be used according to an oncologist’s treatment plan.